In this study, we employed single-prick COVID-19 IgG/IgM Rapid Test Cassettes (Zheijiang Orient Gene Biotech, China) to trace SARS-CoV-2 previous infection in cancer patients treated at the Steve Biko Academic Hospital (SBAH), South Africa, where no specific study of this kind had been performed previously, according to our knowledge. This evidence concerns the gene CD40LG and COVID-19.