NLRP3 and gout: The most remarkable findings regarding the role of the NLRP3 inflammasome in inflammatory joint diseases were identified in the context of microcrystal arthropathies, particularly gouty arthritis; however, recent evidence demonstrates that the NLRP3 inflammasome may also play a pivotal role in the induction of rheumatoid arthritis (RA) and in the pathogenesis of seronegative spondyloarthritis (SpA).