CD40LG and rheumatoid arthritis: In this context, the quantification of synovial tissue inflammation degree in naive RA patients is contingent with symptom duration (being higher if the assessment is performed after 12 months from symptom onset), autoantibody positivity (being higher in ACPA and/or IgM/IgA-RF positive RA), and with treatment response to the first line treatment (being higher in RA patients who do not achieve remission after 6 months of Methotrexate therapy) [30].