In acute COVID-19, this physio-affective phenome was largely explained by the cumulative effects of increased pro-inflammatory cytokines, including IL-6 and soluble advanced glycation products (sRAGEs); changes in acute-phase proteins, including C-reactive protein (CRP) and albumin; lowered calcium (Ca); pneumonia as indicated by chest computerized tomography scan abnormalities (CCTAs); and diminished SpO2 [31]. This evidence concerns the gene CRP and pneumonia.