The immunopathogenesis of the acute infectious phase of COVID-19 comprises activation of the cytokine network with induction of interferons; interleukin (IL) 1, IL-6, IL-12, IL-18, and tumor necrosis factor (TNF) α signaling; activation of the nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome; and activation of key antiviral pathways, toll-like-receptor cascades, and NOD-like receptor signaling [20,21,22,23]. Here, NLRP3 is linked to COVID-19.