GJB2 (Connexin 26) is the gene associated with most common pathologic variants for uSNHL [14,18,19,28], though it has been questioned if autosomal recessive non-syndromic SNHL may be considered a non-syndromic unilateral condition or if the SNHL is always affecting both ears [10]. The gene discussed is GJB2; the disease is sensorineural hearing loss disorder.