The independent prognostic factors associated with OS were Child–Pugh classification (HR = 1.268; 95%CI: 1.001,1.604; p = 0.049), portal vessel invasion (HR = 1.913; 95%CI: 1.561,2.333; p < 0.001), extrahepatic metastasis (HR = 1.720; 95%CI: 1.268, 2.333; p < 0.001), tumor number (HR = 1.341; 95%CI: 1.071, 1.679; p = 0.01), AFP level (HR = 1.268; 95%CI: 1.074,1.498; p = 0.005), longest tumor diameter (HR = 1.011; 95%CI: 1.008, 1.013; p < 0.001), PLT (HR = 1.001; 95%CI: 1.000, 1.002; p = 0.03), and PNI (HR = 0.969; 95%CI: 0.955,0.984; p < 0.001). The gene discussed is AFP; the disease is neoplasm.