First, this is a retrospective study of a relatively small sample size of overweight/obese T2DM subjects recruited from a single center which may have limited the power to detect weak correlations among measured variables; however, the sample size of T2DM participants in this study was sufficient to demonstrate strong correlations between specific lipoprotein subpopulations and the index of insulin resistance LPIR. This evidence concerns the gene INS and type 2 diabetes mellitus.