In a prospective study by Di Lorenzo et al. evaluating the detection of preeclampsia by integrating maternal history, serum biomarkers, and uterine artery Doppler in the first trimester, the authors reported a sensitivity of 60% (TPR) for a 20% FPR for all types of PE when using a combination of UtA-PI, PlGF, and a maternal history of chronic hypertension [47]. The gene discussed is PGF; the disease is preeclampsia.