CCN4 and cardiac hypertrophy: In cardiac myocytes, WNT/ß-catenin signaling antagonizes ANGII-induced myocyte hypertrophy [205], whilst ANGII induces the expression of the WNT/ß-catenin regulated WISP1 (WNT-induced secreted protein-1), a TCF/LEF target for cardiac hypertrophy [206].