KRAS and non-small cell lung carcinoma: Lastly, further highlighting the complexity of the prostaglandins production pathway, a recent study using an in vitro KRAS mutant NSCLC model showed that, unlike COX2, inhibition of PGES creates a pro-cell death state which coincides with accumulation of sphinganine and dihydroceramide C16:0, two sphingolipid species associated with cancer cell death [103].