In sharp contrast, treatment with statins (drugs that lower LDL blood levels) accelerates PDAC growth of Pdx1-Cre;LSL-KrasG12D;Trp53flox/flox mice through TGF-β induction and epithelial to mesenchymal transition (EMT) activation, but dramatically decreases tumor progression in Pdx1-Cre;LSL-KrasG12D;Trp53wt/flox mice, potentially due to a TGF-β-mediated, p53-dependent apoptosis initiation [80,81]. Here, TP53 is linked to neoplasm.