FGFR3 and renal pelvis/ureter urothelial carcinoma: In light of the higher prevalence of UTUC in Asian countries such as Taiwan [1,2,3,4], taken with the significant up-regulation of FGFR3 noted in both Asian and Caucasian patients with advanced UTUC, we reasonably proposed that mutational differences in the FGFR3 gene between Asian and Caucasian populations may be the cause and that the genetic interference of FGFR3 using siRNA may be an effective therapeutic strategy for UTUC treatment regardless of FGFR3 gene mutations.