In addition, Rac1 knockdown decreased the expressions of PAK1- and EMT-related markers including Snail in hypoxia-exposed HCC cells, and the suppression of hypoxia-induced migration-invasive ability was confirmed by inhibition of PAK1 and Snail expression using Rac1 siRNA in HCC cells. Here, SNAI1 is linked to hepatocellular carcinoma.