According to the findings of our results, we hypothesized that YTHDF1 regulates Thrombospondin-1 (THBS1) post-transcriptionally through m6A methylation to promote osteogenic differentiation of MC3T3-E1 cells, providing an important potential for the treatment of peri-implantitis. Here, THBS1 is linked to Peri-Implantitis.