Some studies confirm that curcumin does, in fact, induce apoptosis in CLL B cells, with an EC50 four times lower than that observed in normal mononuclear cellstheThe simultaneous reduction in NFκB at the nuclear level suggests that the action of turmeric is exerted precisely on this molecule, likely through the inhibition of the phosphorylation of IkB. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.