During the evolution of the COVID-19 clinical picture, the secretion of multiple cytokines is closely related to the development of clinical symptoms and, in particular, IL-6 can be involved into vascular leakage, the activation of complement, and the coagulation cascade, leading to the characteristic symptoms of severe forms, such as those that can develop a diffuse intravascular coagulation (DIC) [11,12]. The gene discussed is IL6; the disease is COVID-19.