Consistent with frequent TET2 mutations in DLBCL, Tet2 deletion in HSPCs or B cells in mice (using Vav-Cre or CD19-Cre) caused germinal center hyperplasia and impaired plasma cell differentiation by impairing germinal center B cell epigenome and transcriptome [121,122], ultimately developing B-cell lymphoma [123]. This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.