CD274 and testicular cancer: Since immunosuppression in the TME was frequently reported to be induced by B7/CTLA-4 and PD-1/PD-L1 interactions [37,38,39], we firstly used the TIDE algorithm to predict the response to immune checkpoint blockade (ICB) therapy, including CTLA-4 and PD-1, in testicular cancer and thymoma [40].