The IPA confirmed the enrichment of pathways involved in TME and ECM, which are reported to be essential non-cellular components of TME [34], GPCR, and PI3K activation (as indicated by breast cancer regulation by Stathmin 1 pathway in IPA [35]) in ERFEhigh cancers (Figure 8E and Figures S2–S5). The gene discussed is STMN1; the disease is cancer.