Moreover, Rig is capable of inducing senescence or cell death by apoptosis in several tumor cell lines, both in vitro and in vivo [4,6,12,13,14,15,16,17,18], increasing the production of ROS and altering the expression of numerous proteins involved in apoptosis (p53, BAX, MDM2) and in the formation of metastases (E-cadherins, matrix metalloproteinases 2 and 9) [5]. The gene discussed is TP53; the disease is neoplasm.