In a multivariate analysis, when considering age, β2M, ZAP-70, CD38 and cytogenetic aberrations, low miR-20a expression remained an independent marker predicting short TTT for CLL patients (HR, 2.96; 95% CI, 1.38–6.38; p = 0.006) (Table 4). The gene discussed is B2M; the disease is B-cell chronic lymphocytic leukemia.