SNAI1 and breast carcinoma: Multiple studies have since reported that F-box (FBX) family proteins (FBXL14, FBXO45, FBXO11, FBXO22, FBXW7, FBXL5 and FBXW7) inhibit EMT, metastasis and progression of breast cancer, gastric cancer and non-small lung cancer through proteasome-mediated Snail degradation [7,8,9,10,11,12,13].