BCL2 and neuroblastoma: Whilst in human neuroblastoma cells (SH-SY5Y) [107] exposed to cyclophosphamide it was observed that CA (400 μM) clearly inhibited the intrinsic pathway of apoptosis, confirmed by increased expression of anti-apoptotic protein Bcl-2, and reduced expression of Bax, caspase-3 as well as decreased cyt c release [107], in Human peripheral blood mononuclear cells [108], CA (60–120 μM) inhibition of H2O2-induced apoptosis was Bcl-2 independent, thus revealing different effects depending on the apoptosis-inducing agent or the cell line model used.