It was found that the presence of ascites (p <0.001), main portal vein thrombosis (p = 0.043), albumin (p = 0.007), bilirubin (p = 0.003), platelet count (p = 0.043), total sorafenib doses (p < 0.001), Child–Pugh score (p < 0.001), Child–Pugh grade (p < 0.001), ALBI score (p = 0.004), ALBI grade (p = 0.015), PALBI score (p = 0.006) and PALBI grade (p < 0.001) were associated with OS. The gene discussed is ALB; the disease is Ascites.