On the contrary, kinases IKKβ or TBK1 directly phosphorylate TRIM21 at residue S80 in the LxxIS motif of the RING domain to prevent B-Box inhibition, enhancing E2 binding, RING catalysis, NF-κB activation, and cytokine expression after DNA or RNA viruses’ infection [58]. This evidence concerns the gene TRIM21 and infection.