BCL2 and gastric cancer: A study performed in both an in vitro and in vivo gastric cancer cell model demonstrated that hesperetin induced the intrinsic apoptotic mechanism by increasing ROS levels; in particular, it determined apaf-1 and bax expression upregulation, caspases-3 and -9 activation, MMP and bcl-2 expression decrease, cytochrome c release and DNA fragmentation [126].