The same effects on BCL2 family members was found in the T24 bladder cancer cell line, where it upregulated bax, bad and bak and downregulated bcl-2, bcl-xL and mcl-1 protein expression; these events were associated with caspase-9, -3, -7 activation, cytochrome c release and parp-1 cleavage [121]. The gene discussed is BCL2; the disease is urinary bladder cancer.