On the other hand, changes in mitochondria function, as well as the p53-dependent bax upregulation in breast [169] and colon cancer cells [36] and the bcl-2 down-regulation in laryngeal [170], breast [171] and prostate [172] cancer cells, are the most crucial changes that occur in curcumin-mediated intrinsic apoptosis. The gene discussed is BAX; the disease is malignant colon neoplasm.