It was found that lncRNA MALAT1 is widely expressed in CMs under high glucose, and lncRNA MALAT1 positively regulate the nuclear translocation of the YAP by binding to the cAMP response element-binding protein (CREB), thereby increasing the inflammatory response and collagen accumulation in cardiac fibroblasts and diabetic cardiomyopathy mice in a high-glucose microenvironment [121]. This evidence concerns the gene MALAT1 and diabetic cardiomyopathy.