YAP1 and atherosclerosis: In addition, the YAP in macrophages acts as an IL-1β-triggered inducer through the tumor necrosis factor-associated factor-6 (TRAF6)-mediated ubiquitination of Lys63 and the subsequent destruction of angiomotin (AMOT) binding, thereby promoting the release of chemotactic mediators and accelerating the development of atherosclerosis [96,97].