Mice lacking an epicardial YAP and TAZ develop severe pericardial inflammation and myocardial fibrosis after an MI, whereas the local targeted injection of interferon-γ (IFN-γ) after an MI reduced the Treg infiltration into the injured myocardium in YAP/TAZ mutants and reduced myocardial fibrosis [74]. This evidence concerns the gene YAP1 and Myocardial fibrosis.