Gap19, a Cx43 mimetic peptide, has also been shown to target YAP signaling in reactive astrocytes after an intracerebral hemorrhage injury to reduce the expression of proinflammatory cytokines (IL-1β, IL-6, TNF-α, and MCP1), increase anti-inflammatory cytokines (IL-4 and IL-10), and increase the neuronal cell survival. This evidence concerns the gene TNF and intracerebral hemorrhage.