BMPR2 and Oligodontia: In this study, all the variants—Arg272Cys, Val348Ile, and Lys477Glu—caused different conformational changes in the BMPR2 kinase domain, demonstrating that the kinase domain represents a germline variant hotspot in nonsyndromic oligodontia and plays a crucial role in the pathogenesis of nonsyndromic oligodontia.