ALOX5 and vascular disorder: There are six known functional LOX genes in humans (ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOXE3), but only three of them, 5-LOX, 12-LOX (platelet-type), and 15-LOX (reticulocyte-type), appear to be important for vascular disorders [34].