The expression profile of seven genes described to be involved in epigenetic regulation (Dnmt1, Dnmt3a, Dnmt3b, Hdac1, Hdac2, Tet1, and Tet2) was analyzed by quantitative real-time PCR (RT-qPCR) in the thalamus of Tg338 mice, a transgenic scrapie mouse model expressing a transgenic VRQ allele of the ovine PRNP gene under the ovine PrP promoter [35,36]. This evidence concerns the gene PRNP and scrapie.