Govindarajulu et al. have reviewed the potential of several nutraceutical-based natural compounds that activate SIRT3 including curcumin, salidroside, phloretin, acacetin, spinacetin, theacrine, trilobatin, sesamin, sesamol, and dihydromyricetin for the treatment of neurodegenerative diseases [178]. The gene discussed is SIRT3; the disease is neurodegenerative disease.