Although the overexpression of cyclin D1 (CCND1), caused by the t(11;14) (q13;q32) translocation is a major hallmark for MCL, some patients lack this translocation, and approximately 2% of healthy individuals harbor it [11], suggesting that other key factors and pathways are required for the pathogenesis and progression of MCL. Here, CCND1 is linked to mantle cell lymphoma.