MAP2K1 and cancer: It is of interest to note that multiple cancer-related genes were also significantly increased in FARSAKD Jeko cells, including activating transcription factor 5 (ATF5), eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), telomerase reverse transcriptase (TERT), KRAS proto-oncogene (KRAS), mitogen-activated protein kinase (MAPK) kinase 1 (MAP2K1) and MAPK1, which are key regulators contributing to the development and progression of MCL and other NHLs [12,13,23,24,25] (Supplementary Figure S2).