PIK3CA and mantle cell lymphoma: These findings support a hypothetic molecular event in the FARSAKD MCL cells (Figure 6D), in which knockdown of FARSA enhances the PI3K-AKT signaling, contributing to the accelerated cell cycle by inactivating FOXO1; on the other hand, the enhanced activation of AKT is another contributor to the pathogenesis and survival of MCL [29].