For example, threonyl-tRNA synthetase 1 (TARS1), glycyl-tRNA synthetase 1 (GARS1), glutamyl-prolyl-tRNA synthetase 1 (EPRS1), and phenylalanyl-tRNA synthetase subunit alpha (FARSA) are differentially upregulated across many cancer types, whereas a few cyto-aaRSs, including tryptophanyl-tRNA synthetase 1 (WARS1) and isoleucyl-tRNA synthetase 1 (IARS1), are downregulated, suggesting that these cyto-aaRSs possess certain specific roles in tumorigenesis [2]. This evidence concerns the gene IARS1 and cancer.