Tumor-intrinsic signaling pathways, such as WNT/β-catenin signaling, STAT3 signaling, p53 signaling, and RAS/RAF/MAPK and JAK2/STAT1 signaling pathways, have a key role in regulating the immunosuppressive tumor microenvironment and in tumor immune escape [83,84]. Here, JAK2 is linked to neoplasm.