NLY01, a potent glucagon-like peptide-1 receptor (GLP1R) agonist, has been found to block A1 neurotoxic astrocyte conversion by microglia, and it was shown to prolong the survival of dopaminergic neurons and reduce the pathology of hA53T α-synuclein transgenic mice, a PD model [89]. The gene discussed is GLP1R; the disease is Parkinson disease.