In recent years, many reviews have been focused on these proteins, some addressing one group in particular, group IB [8], including IIA [13,14,16,35,36], II E, D, and F [18], as well as sPLA2s of group V [24] and group X [27], while others relate to the role of sPLA2s in macrophage modulation [37], in insulin resistance and metabolism [38], in acute lung injury [15], as targets of anti-inflammatory drugs [39], in viral diseases [40], and to their non-enzymatic activity [34]. The gene discussed is PLA2G2D; the disease is viral infectious disease.