The S80G mutation of PLA2-IID (S80G considers the numbering without the signal peptide), associated with weight loss in subjects with chronic obstructive pulmonary disease (COPD) [19], could alter a phosphorylation site by glycogen synthase kinase-3 (GSK3), a kinase involved in numerous biological processes and diseases [59], which is also a regulator of metabolic pathways [60] involved in muscle atrophy in COPD [61]. This evidence concerns the gene PLA2G2D and chronic obstructive pulmonary disease.