GPT and coronary artery disorder: One study examining the association between elevated serum alanine aminotransferase (ALT) activity and the 10-year risk of CHD, as estimated using the Framingham risk score, showed that relative increase in risk was much greater in women than in men (hazard ratio 2.14 vs. 1.28) [90] despite the fact that women have a lower absolute risk of CHD than men.