Changes in the expression of individual P2X have also been found in inflammatory and chronic pain (P2X3, P2X2/3), epilepsy (P2X2, P2X4 and P2X6), depression and some cancers (P2X7) [86], leading to experimental therapeutic approaches using P2X agonists [86,87]. Here, P2RX2 is linked to depressive symptom measurement.