MAPK8 and hepatocellular carcinoma: Baicalein (5,6,7-trihydroxyflavone), a flavone originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora may trigger ER stress, regulating CHOP, JNK (upregulation) and Bcl-2 family (downregulation), thus, it can induce apoptosis and autophagy in hepatocellular carcinoma cells (HCC) [168].