ECGC, due to GRP78 inhibition, may greatly improve the therapeutic effect of temozolomide to cause glioblastoma apoptosis [182] from in vivo studies, for its effect on GRP78, EGCG could protect against cisplatin-induced nephrotoxicity by suppression of ER stress-mediated apoptosis in mouse renal tubular epithelial cells [183]. The gene discussed is HSPA5; the disease is glioblastoma.