For example, it is well-known that an important expression of GRP78 is correlated with poor prognosis and lymph node metastasis in gastric tumours [117]; moreover, these data are reinforced by preclinical studies which show how the silencing of GRP78 reduces invasion in vitro and tumour growth and metastasis in vivo [117]. This evidence concerns the gene HSPA5 and gastric neoplasm.