RCAN1 and coronary artery disorder: To examine if RCAN1 contributes to non-syndromic cases of CHDs, RCAN1 exons and flanking regions from 128 patients with non-syndromic CHD and 150 normal controls were sequenced, leading to the detection of six novel heterozygous variants in the RCAN1 gene in CHD cases, although they were absent in control cases.