Staquicini and colleagues [61] designed and developed a phage vaccine for COVID-19 by using dual ligand peptide-targeted phages and adeno-associated virus/phage (AAVP) particles which showed strong targeted humoral responses against the S protein and were considered promising candidates for COVID-19 vaccination [61] A strong systemic and specific immune response was observed with phage particles against SARS-CoV-2 in immune-competent mice by aerosol pulmonary vaccination [61]. This evidence concerns the gene PROS1 and COVID-19.