Corroborating an important role of PI3K in PI3K/Akt/mTOR signaling and epilepsy further, a selective inhibitor of PI3K, LY294002, exerts a similar anticonvulsant effect in zebrafish treated with pentylenetetrazole, reducing both motor (clonic seizures) and molecular (c-fos brain expression) biomarkers of epilepsy in larval fish [106]. The gene discussed is FOS; the disease is epilepsy.