Albeit a highly polygenic brain disorder and not a ‘true’ mTORopathy per se, ASD has neuronal deficiencies linked to mTOR dysregulation [50,51], and epilepsy is frequently comorbid with ASD, further supporting the putative shared pathogenetic link between mTOR deficits, epilepsy and neurodevelopmental disorders in general. This evidence concerns the gene MTOR and brain disorder.