MTOR and channelopathy: Furthermore, given such critical biological roles of the mTOR signaling pathway, it is also possible that mTORopathies are just too broad of an umbrella disorder group, which may not only be less specific (and, hence, diagnostically confusing) in terms of mimicking individual symptoms in animal models, but can also involve a substantial pathogenetic overlap with ‘downstream’ pathologies that may or may not directly stem from mTOR deficits per se (e.g., some channelopathies, tauopathies or gross neurodevelopmental disorders).