TNF and rheumatoid arthritis: As a matter of fact, RA treatment is based on conventional and biological therapies, including TNF inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab), abatacept, rituximab, IL-6 inhibitors (tocilizumab and sarilumab), biosimilars, and small oral molecules (the JAK inhibitors tofacitinib and baricitinib) [76,77].