Consistent with this, we noticed that patients in the aging subtype had a higher expression of SASP, including a series of interleukins (IL-6, IL-13, and IL-15), chemokines (CCL3, CCL8, CCL13, and CCL26), matrix proteases (MMP-1, MMP-9, MMP-13, and MMP-14), receptors or ligands (TNFRSF1A, TNFRSF1B, and PLAUR), etc. The pleiotropic effect of SASP can facilitate tumor invasion and metastasis. The gene discussed is MMP13; the disease is neoplasm.