FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: A missense loss-of-function mutation within the FOXP3 locus can result in self-reactive lymphocytes that can lead to the development of severe autoimmunity in scurfy mice or cause a rare, but severe, disease IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome in humans [1,2,3].