In the Cox regression analysis, we found that hypertension (HR 0.818, CI 95% [0.669–0.999]), higher ET-1 (HR 0.859, CI 95% [0.839–0.979]), lymphocytes (HR 0.820, CI 95% [0.758–0.987]), LVEF (HR 0.876, CI 95% [0.760–0.992]), and ED (HR 0.751, CI 95% [0.624–0.905]) inversely predicted a lower likelihood of CRTd response, whereas higher miR-130a-5p (HR 1.490, CI 95% [1.014–2.188]) directly predicted CRTd response (Table 3). This evidence concerns the gene EDN1 and Hypertension.