TNF and cancer: Belongs to the cell surface receptor proteins of the TIM family;Transmembrane protein of T lymphocytes (CD4+ and CD8+ T cells), myeloid cells (monocytes, macrophages, DCs, mast cells, NK cells) or various cells in various types of cancers;Mediates depletion of CD8+ T cells for proliferation and secretion of cytokines such as TNF-alpha, IFN-gamma and IL-2.