Belongs to the superfamily of TNF receptors;Cytoplasmic region of this receptor binds to several members of the TNF receptor-associated factor (TRAF) family, which may mediate signal transduction pathways that activate the immune response;HVEM overexpression in NSCLC patients was significant in patients with N2 lymph node metastases;Shows a negative correlation with PD-L1 expression in NSCLC patients. Here, CD274 is linked to non-small cell lung carcinoma.