Indeed, while one study reported that IL-1 levels were elevated more in the stratum corneum of AD patients bearing mutations for the skin-barrier-related gene filaggrin, and this expression profile was also reported in a murine homolog of filaggrin deficiency [28]; a negative association was also found between IL1B and AD disease [29]. This evidence concerns the gene IL1B and hyperinsulinemic hypoglycemia, familial, 4.