AQP4 and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: In addition to DMD, patients with other NMDs, including Fukuyama-type congenital muscular dystrophy (FCMD), dysferlinopathy, and sarcoglycanopathy, also revealed reduced levels of AQP4, although its roles in pathogenesis and pathophysiology are unclear [74].