FN1 and cancer: In NSCLC adenocarcinoma cells, TGFβ induces the overexpression of the αvβ6 integrin receptor, and it has been observed that, in lung carcinomas, αvβ6 integrin promotes the adhesion of cancer cells to fibronectin, enhances tumorigenicity, and confers resistance to apoptosis induced by standard chemotherapeutic agents [32].