These data highlight the implications of GVB in the mechanisms of tumor progression, and that tumor-associated microbiota is pivotal in this process; the results are even more interesting given that administration of antibiotics before the onset of metastases in mice was able to reduce the expression of PV-1 in the primary tumor as well as the number of liver lesions [108], opening the field also to interventional studies. This evidence concerns the gene PLVAP and neoplasm.