An increase in IL-1β, IL-18, TNF-α, inflammasome NLRP3 activation, astrogliosis, and BBB permeability in the brain areas involved in the control of the intake of food such as the LH and hippocampus are the hallmarks of obesity-induced neuroinflammation. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.