In this context, the NLRP3 inflammasome can be activated by cholesterol crystals and ceramides [101] due to the exacerbation of lipolysis in obesity [102], but can also be activated by bacteria, fungi, and viruses; however, NLRP3 is associated with metabolic and inflammatory conditions such as obesity [103,104]. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.