PRKDC and hepatocellular carcinoma: However, a study of liver cancer cell lines (HuH6, SNU449, and THLE-2 cells) and normal cell lines has found that metastasis-associated 1 protein (MTA1) reduces the phosphorylation of H1.2 at T146 by proteasomal degradation of DNA-PK, which in turn promotes hepatocellular carcinoma (HCC).