VEGFA and Alzheimer disease: In that report, the major alterations in cerebrovascular processes of OXYS rats proved to be associated with blood vessel development, circulatory system processes, the VEGF signaling pathway, and vascular smooth muscle contraction; at preclinical (age P20) and early stages (5 months) of the AD-like pathology, these processes were upregulated and then downregulated by the age of 18 months.