Our current comparative gene expression analysis in the PFC and hippocampus of OXYS rats in the period preceding the development of AD signs and during their manifestation and active progression revealed 36 common (among five ages in total) DEGs, and three of them had unidirectional expression changes (upregulation) throughout the lifespan (Smpd4, Thoc3, and Exosc8). The gene discussed is SMPD4; the disease is Alzheimer disease.